Detection of Hpdel in healthy individuals and cancer patients in Taiwan
Identifieur interne : 001882 ( Main/Exploration ); précédent : 001881; suivant : 001883Detection of Hpdel in healthy individuals and cancer patients in Taiwan
Auteurs : Yu-Chieh Su ; Yi-Chun Chen ; Szu-Chin Li ; Ching-Chih Lee ; Ya-Ting Tung [République populaire de Chine]Source :
- Special Issue: Proteomics and Biomarkers [ 1437-4331 ] ; 2009.
English descriptors
- Teeft :
- Allele, Allele frequency, Anaphylactic transfusion reactions, Antihaptoglobin antibody, Blood products, Blood samples, Buddhist dalin, Cancer patients, Cancer stage, Carcinoma, Case reports, Cell carcinoma, Chem, Clin, Clin chem, Clin pathol, Clinical characteristics, Clinical stage, Colon rectal cancer, Congenital, Different cancer groups, General hospital, Genetic survey, Genotype, Haptoglobin, Haptoglobin deficiency, Haptoglobin types, Healthy controls, Healthy group, Healthy individuals, Healthy subjects, Healthy taiwanese volunteers, Hepatocelluar carcinoma, Hpdel, Hpdel allele, Hpdel frequency, Hpdel genotype distribution, Hpdel homozygosity, Hpdel variant, Internal medicine, Koda, Nasopharyngeal carcinoma, Other areas, Phenotype, Polymerase chain reaction, Polymorphism, Promoter region, Severe transfusion reactions, Significant difference, Soejima, Such reactions, Taiwanese population, Transfusion, Various cancers, Various types.
Abstract
Background: We investigated the genotypic distribution of Hpdel in healthy subjects and cancer patients in Taiwan. Methods: Blood samples were collected from 244 randomly selected healthy Taiwanese volunteers and 737 patients with various cancers. Samples were analyzed for the haptoglobin (Hp) gene, and the presence of the Hpdel allele was determined from genomic DNA by an Hpdel-specific polymerase chain reaction (PCR) method. The plasma concentration of Hp was also determined. Results: The frequency of the Hpdel allele was calculated to be 0.029, and was not different between the healthy subjects and patients with cancer. The prevalence of Hp deficiency caused by Hpdel homozygosity was estimated to be ∼0.85 in 1000. Fifty-seven subjects were reclassified from homozygous Hp1 or Hp2 to Hp1/Hpdel or Hp2/Hpdel genotypes. The Hpdel allele is not associated with prevalence, severity or stage of any cancer. Conclusions: Congenital Hp deficiency caused by Hpdel homozygosity is a condition present in Taiwan with a relatively high frequency. However, the Hpdel variant does not play a role in cancer. Clin Chem Lab Med 2009;47:745–9.
Url:
DOI: 10.1515/CCLM.2009.156
Affiliations:
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Su</name></author><author><name sortKey="Chen, Yi Chun" sort="Chen, Yi Chun" uniqKey="Chen Y" first="Yi-Chun" last="Chen">Yi-Chun Chen</name></author><author><name sortKey="Li, Szu Chin" sort="Li, Szu Chin" uniqKey="Li S" first="Szu-Chin" last="Li">Szu-Chin Li</name></author><author><name sortKey="Lee, Ching Chih" sort="Lee, Ching Chih" uniqKey="Lee C" first="Ching-Chih" last="Lee">Ching-Chih Lee</name></author><author><name sortKey="Tung, Ya Ting" sort="Tung, Ya Ting" uniqKey="Tung Y" first="Ya-Ting" last="Tung">Ya-Ting Tung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="issue">Special Issue: Proteomics and Biomarkers</title><title level="j" type="abbrev">Clinical Chemistry and Laboratory Medicine</title><idno type="eISSN">1437-4331</idno><idno type="ISSN">1434-6621</idno><imprint><publisher>Walter de Gruyter</publisher><date>2009</date><date type="e-published">2009</date><biblScope unit="vol">47</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="745">745</biblScope><biblScope unit="page" to="749">749</biblScope><biblScope unit="ref-count">27</biblScope><biblScope unit="fig-count">0</biblScope><biblScope unit="table-count">4</biblScope></imprint><idno type="ISSN">1434-6621</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1434-6621</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Allele frequency</term><term>Anaphylactic transfusion reactions</term><term>Antihaptoglobin antibody</term><term>Blood products</term><term>Blood samples</term><term>Buddhist dalin</term><term>Cancer patients</term><term>Cancer stage</term><term>Carcinoma</term><term>Case reports</term><term>Cell carcinoma</term><term>Chem</term><term>Clin</term><term>Clin chem</term><term>Clin pathol</term><term>Clinical characteristics</term><term>Clinical stage</term><term>Colon rectal cancer</term><term>Congenital</term><term>Different cancer groups</term><term>General hospital</term><term>Genetic survey</term><term>Genotype</term><term>Haptoglobin</term><term>Haptoglobin deficiency</term><term>Haptoglobin types</term><term>Healthy controls</term><term>Healthy group</term><term>Healthy individuals</term><term>Healthy subjects</term><term>Healthy taiwanese volunteers</term><term>Hepatocelluar carcinoma</term><term>Hpdel</term><term>Hpdel allele</term><term>Hpdel frequency</term><term>Hpdel genotype distribution</term><term>Hpdel homozygosity</term><term>Hpdel variant</term><term>Internal medicine</term><term>Koda</term><term>Nasopharyngeal carcinoma</term><term>Other areas</term><term>Phenotype</term><term>Polymerase chain reaction</term><term>Polymorphism</term><term>Promoter region</term><term>Severe transfusion reactions</term><term>Significant difference</term><term>Soejima</term><term>Such reactions</term><term>Taiwanese population</term><term>Transfusion</term><term>Various cancers</term><term>Various types</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We investigated the genotypic distribution of Hpdel in healthy subjects and cancer patients in Taiwan. Methods: Blood samples were collected from 244 randomly selected healthy Taiwanese volunteers and 737 patients with various cancers. Samples were analyzed for the haptoglobin (Hp) gene, and the presence of the Hpdel allele was determined from genomic DNA by an Hpdel-specific polymerase chain reaction (PCR) method. The plasma concentration of Hp was also determined. Results: The frequency of the Hpdel allele was calculated to be 0.029, and was not different between the healthy subjects and patients with cancer. The prevalence of Hp deficiency caused by Hpdel homozygosity was estimated to be ∼0.85 in 1000. Fifty-seven subjects were reclassified from homozygous Hp1 or Hp2 to Hp1/Hpdel or Hp2/Hpdel genotypes. The Hpdel allele is not associated with prevalence, severity or stage of any cancer. Conclusions: Congenital Hp deficiency caused by Hpdel homozygosity is a condition present in Taiwan with a relatively high frequency. However, the Hpdel variant does not play a role in cancer. Clin Chem Lab Med 2009;47:745–9.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Yi Chun" sort="Chen, Yi Chun" uniqKey="Chen Y" first="Yi-Chun" last="Chen">Yi-Chun Chen</name><name sortKey="Lee, Ching Chih" sort="Lee, Ching Chih" uniqKey="Lee C" first="Ching-Chih" last="Lee">Ching-Chih Lee</name><name sortKey="Li, Szu Chin" sort="Li, Szu Chin" uniqKey="Li S" first="Szu-Chin" last="Li">Szu-Chin Li</name><name sortKey="Su, Yu Chieh" sort="Su, Yu Chieh" uniqKey="Su Y" first="Yu-Chieh" last="Su">Yu-Chieh Su</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tung, Ya Ting" sort="Tung, Ya Ting" uniqKey="Tung Y" first="Ya-Ting" last="Tung">Ya-Ting Tung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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